Dissolution Testing Using Fiber Optics— A Regulatory Perspective

Practical Considerations When Using Fiber Optics for Dissolution Testing

Introduction The UV fiber optics system has emerged in dissolution testing of solid dosage forms as a useful alternative to conventional dissolution tests in both research & development and quality control. The system allows continuous in situ analysis of the drug concentration without the need for sample withdrawal and preparation. Therefore, this technique not only facilitates automation, but...

Multimode Fiber Using Adaptive Optics

Transmitter-based adaptive optics and receiver-based single-mode filtering are combined to compensate modal dispersion in multimode fiber (MMF). A liquid-crystal spatial light modulator controls the launched field pattern for ten 10-Gb/s nonreturn-to-zero channels, wavelength-division multiplexed on a 200-GHz grid in the C-band. Error-free transmission through 2.2 km of 50m graded-index MMF is ...

Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective

The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and the agencies that regulate them. These challenges include developing and validating the test methods, ensuring that methods are appropriately discriminatory, and addressing the potential for an in vivo–in vitro correlation (IVIVC). Di...

Dissolution: a Continuing Perspective

Fiber Optics

Dramatic improvements in the development of low-loss materials for optical fibers are responsible for the commercial viability of fiber-optic communications. Corning Incorporated pioneered the development and manufacture of ultra-low-loss glass fibers. C 0 R N I N G 272 Fundamentals of Photonics